3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide

Base Information

• Chemical Name: 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide
• CAS No.: 1040725-56-1
• Molecular Formula: C₁₈H₁₅N₃O₂S₂
• Molecular Weight: 369.468

Synonyms:3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide

Chemical Property of 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide

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Technology Process of 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide

There total 1 articles about 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione-1-yl acetonitrile (1040725-54-9) + thioacetamide (62-55-5) → 3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide (1040725-56-1)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 1.5h;

DOI:10.1002/jhet.5570450335

Reference yield: 68.0%

3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide (1040725-56-1) + 4-chlorobenzoylmethyl bromide (536-38-9) → 5-(4'-chlorophenyl)thiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione (1040725-62-9)

Guidance literature:

With acetic acid; Heating;

DOI:10.1002/jhet.5570450335

Reference yield: 66.0%

3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione-1-yl-thioacetamide (1040725-56-1) + α-bromoacetophenone (70-11-1) → 5-phenylthiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione (1040725-58-3)

Guidance literature:

With acetic acid; for 0.75h; Heating;

DOI:10.1002/jhet.5570450335

upstream raw materials:

3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione-1-yl acetonitrile

thioacetamide

Downstream raw materials:

5-phenylthiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione

5-(4-methylphenyl)thiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione

5-(4'-chlorophenyl)thiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione

5-(4'-bromophenyl)thiazolyl methyl-3'-phenyl-spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)dione

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