5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

Base Information

Chemical Name:5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt
CAS No.:1003567-13-2
Molecular Formula:C₂HF₃O₂*C₂₃H₂₆Cl₂N₂O₅
Molecular Weight:595.4
Hs Code.:

5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

Synonyms:5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

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Chemical Property of 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

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Technology Process of 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

There total 4 articles about 5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1003567-11-0
5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-(p-methoxybenzyloxy)-N-methylbenzamide

: 76-05-1
trifluoroacetic acid

: 1003567-13-2
5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

Guidance literature:: In toluene; at 20 - 25 ℃; for 3h; Product distribution / selectivity;

Reference yield: 72.0%

: 1003567-10-9
5-chloro-4-(4-methoxybenzyloxy)-N-methyl-2-((2S)-oxiran-2-ylmethoxy)benzamide

: 71916-97-7
5-chloro-2,3-dihydrospiro

: 76-05-1
trifluoroacetic acid

: 1003567-13-2
5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

Guidance literature:: 5-chloro-4-(4-methoxybenzyloxy)-N-methyl-2-((2S)-oxiran-2-ylmethoxy)benzamide; 5-chloro-2,3-dihydrospiro; In ethanol; at 80 ℃;

trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 2h; Product distribution / selectivity;

Reference yield: 58.0%

: 1003567-26-7
5-chloro-4-hydroxy-N-methyl-2-[(2S)-oxiran-2-ylmethoxy]benzamide

: 76-05-1
trifluoroacetic acid

: 1003567-13-2
5-chloro-2-{[(2S)-3-(5-chloro-3H-spiro[1-benzofuran-2,4'-piperidin]-1'-yl)-2-hydroxypropyl]oxy}-4-hydroxy-N-methylbenzamide trifluoroacetic acid salt

Guidance literature:: 5-chloro-4-hydroxy-N-methyl-2-[(2S)-oxiran-2-ylmethoxy]benzamide; 5-chloro-2,3-dihydrospiro; With lithium perchlorate; In acetonitrile; for 4h; Heating / reflux;

trifluoroacetic acid; In water; acetonitrile; Product distribution / selectivity;