(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

Base Information

Chemical Name:(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester
CAS No.:1426298-01-2
Molecular Formula:C₁₇H₂₆O₇S
Molecular Weight:374.455
Hs Code.:

Synonyms:(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

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Chemical Property of (S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

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Technology Process of (S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

There total 7 articles about (S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1426298-00-1
(R)-acetic acid 3-(3,4-diethoxyphenyl)-2-hydroxymethylpropyl ester

: 124-63-0
methanesulfonyl chloride

: 1426298-01-2
(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2012.11.031

Reference yield:

: 83459-29-4
(3,4-diethoxyphenyl)methanol

: 1426298-01-2
(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

2.2: 25 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / Reflux

4.1: Amano lipase-PS / tetrahydrofuran; di-isopropyl ether / 2 h / 20 °C / Enzymatic reaction

5.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; Amano lipase-PS; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; di-isopropyl ether; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.ejmech.2012.11.031

Reference yield:

: 1426297-99-5
2-(3,4-diethoxybenzyl)malonic acid diethyl ester

: 1426298-01-2
(S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / Reflux

2: Amano lipase-PS / tetrahydrofuran; di-isopropyl ether / 2 h / 20 °C / Enzymatic reaction

3: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With lithium aluminium tetrahydride; Amano lipase-PS; triethylamine; In tetrahydrofuran; dichloromethane; di-isopropyl ether;
DOI:10.1016/j.ejmech.2012.11.031