83459-29-4

Basic information

• Product Name: 3,4-Diethoxybenzyl alcohol
• Synonyms: 3,4-DIETHOXYBENZYL ALCOHOL;RARECHEM AL BD 0251;3,4-diethoxyphenyl methanol;3,4-Diethoxybenzyl alcohol 97%
• CAS NO: 83459-29-4
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 83459-29-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 39-43 °C(lit.)
• Boiling Point: 308.2 °C at 760 mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0.000299mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: 3,4-Diethoxybenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Diethoxybenzyl alcohol(83459-29-4)
• EPA Substance Registry System: 3,4-Diethoxybenzyl alcohol(83459-29-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 83459-29-4(Hazardous Substances Data)

Usage

General Description

3,4-Diethoxybenzyl alcohol can be prepared from 3,4-diethoxybenzaldehyde.

InChI:InChI=1/C11H16O3/c1-3-13-10-6-5-9(8-12)7-11(10)14-4-2/h5-7,12H,3-4,8H2,1-2H3

Upstream product

• 139-85-5 3,4-dihydroxybenzaldehyde 
• 5409-31-4 3,4-diethoxybenzoic acid 
• 2029-94-9 3,4-diethoxybenzaldehyde 
• 2539-53-9 4-ethoxy-3-hydroxybenzaldehyde 

Downstream Products

• 1426298-01-2 (S)-acetic acid 3-(3,4-diethoxyphenyl)-2-methanesulfonyloxymethylpropyl ester 
• 1426297-78-0 (R)-4-(3,4-diethoxybenzyl)dihydrofuran-2-one 
• 1426298-00-1 (R)-acetic acid 3-(3,4-diethoxyphenyl)-2-hydroxymethylpropyl ester 
• 1426297-99-5 2-(3,4-diethoxybenzyl)malonic acid diethyl ester 
• 1426297-96-2 C₂₄H₃₀O₆ 
• 1426297-95-1 C₂₃H₂₈O₆ 
• 1426297-87-1 (3R,4R)-3-(4-benzyloxy-3-ethoxybenzyl)-4-(3,4-diethoxybenzyl)dihydrofuran-2-one 
• 1426297-86-0 (3R,4R)-3-(4-benzyloxy-3-methoxybenzyl)-4-(3,4-diethoxybenzyl)dihydrofuran-2-one 
• 113475-81-3 Pentanedioic acid bis-(4,5-diethoxy-2-nitro-benzyl) ester 
• 153742-08-6 dimethyl 2-(3,4-diethoxyphenyl)-2-methyl malonate 
• 153742-18-8 methyl 2-cyano-2-(3,4-diethoxyphenyl) propionate 
• 153742-17-7 methyl 2-cyano-2-(3,4-diethoxyphenyl) acetate 
• 27472-21-5 3,4-diethoxyphenylacetonitrile 
• 113475-80-2 Pentanedioic acid bis-(3,4-diethoxy-benzyl) ester 

Relevant articles and documents

New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities

An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure–activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their phenyl ring affected the activity and the cytotoxicity of compounds. In addition, physicochemical parameters were calculated (log P, log D, ligand efficiency) or determined experimentally (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3(trifluoromethyl)benzamide possessed good physicochemical properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50 (NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50 (K1 ) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved.

Highly chemoselective hydrogenation of active benzaldehydes to benzyl alcohols catalyzed by bimetallic nanoparticles

By using novel Pd/Ni bimetallic nanoparticles as a catalyst, the active benzaldehydes were hydrogenated to the corresponding benzyl alcohols as unique products in practical quantitative yields. The undesired catalytic hydrogenolysis of the benzyl alcohol was inhibited completely. By using this hydrogenation as a key step, the total synthesis of the natural product gastrodin was achieved with less total steps and a higher total yield.

Cyclic compounds and uses thereof

Compounds of general formula (1) R1—X1—W—X2—Z1—Z2—R2 or salts thereof, exhibiting preventive and therapeutic effects against HIV infectious diseases wherein R1is an optionally substituted five- or six-membered ring group; X1is a free valency or the like; W is a divalent group represented by, e. g., general formula (2) (wherein A and B are each an optionally substituted five- to seven-membered ring; E1and E4are each optionally substituted carbon or the like; E2and E3are each oxygen or the like; and a and b are each a single bond or a double bond); X2is a divalent group constituting a straight chain moiety; Z1is a divalent cyclic group or the like; Z2is a free valency or the like; and R2is optionally substituted amino or the like.