N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

Base Information

Chemical Name:N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide
CAS No.:330941-36-1
Molecular Formula:C₂₃H₁₉BrFN₅O₂
Molecular Weight:496.339
Hs Code.:

Synonyms:N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

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Chemical Property of N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

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Technology Process of N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

There total 5 articles about N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 330943-05-0
N-(5-bromo-2-pyridinyl)-(2-(4-cyanophenylcarbonyl)amino)-5-fluorophenylcarboxamide

: 109-81-9
N-methyl-ethane-1,2-diamine

: 330941-36-1
N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

Guidance literature:: With hydrogenchloride; In methanol; water; acetonitrile;

Reference yield:

: 330943-03-8
N-(5-bromo-2-pyridinyl)-(2-amino)-5-fluorophenylcarboxamide

: 330941-36-1
N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane / 20 °C

2.1: hydrogenchloride / methanol / 0 - 20 °C

2.2: 20 °C

With pyridine; hydrogenchloride; In methanol; dichloromethane;

Reference yield:

: 330943-02-7
N-(5-bromo-2-pyridinyl)(2-nitro)-5-fluorophenylcarboxamide

: 330941-36-1
N-(5-bromo-2-pyridinyl)-(2-(4-(1-methyl-2-imadazolin-2-yl)phenylcarbonyl)amino)-5-fluorophenylcarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / ethyl acetate / 4 h / Reflux

2.1: pyridine / dichloromethane / 20 °C

3.1: hydrogenchloride / methanol / 0 - 20 °C

3.2: 20 °C

With pyridine; hydrogenchloride; tin(II) chloride dihdyrate; In methanol; dichloromethane; ethyl acetate;