6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

Base Information

Chemical Name:6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole
CAS No.:314746-03-7
Molecular Formula:C₃₁H₂₅N₃O₂
Molecular Weight:471.558
Hs Code.:

Synonyms:6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

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Chemical Property of 6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

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Technology Process of 6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

There total 12 articles about 6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 180340-05-0
4-[([1,1'-biphenyl]-2-carbonyl)amino]-benzoyl chloride

: 5698-18-0
3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

: 314746-03-7
6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 544694-09-9
(4-amino-phenyl)-(1,3,4,5-tetrahydro-azepino[4,3,2-cd]indol-6-yl)-methanone

: 314746-03-7
6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(02)01059-4

Reference yield:

: 4769-97-5
4-nitro-1H-indoIe

: 314746-03-7
6-[4-[[(2-biphenyl)carbonyl]amino]benzoyl]-3,4,5,6-tetrahydro-1H-azepino[4,3,2-cd]indole

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid

2.1: benzene / Heating / reflux

3.1: hydrogen / palladium on activated charcoal / ethanol

4.1: 200 - 220 °C / Neat (no solvent)

5.1: potassium hydroxide / water / Heating / reflux

6.1: 150 - 170 °C / Neat (no solvent)

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / Heating / reflux

7.2: 0 - 20 °C

8.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; benzene;