5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

Base Information

Chemical Name:5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole
CAS No.:1251443-45-4
Molecular Formula:C₁₆H₁₅ClINO₂S
Molecular Weight:447.724
Hs Code.:

Synonyms:5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

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Chemical Property of 5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

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Technology Process of 5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

There total 5 articles about 5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 66236-20-2
N-(2-allyl-4-chloro-phenyl)-4-methyl-benzenesulfonamide

: 1251443-45-4
5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

Guidance literature:: With [bis(acetoxy)iodo]benzene; potassium iodide; In dichloromethane; at 20 ℃; for 24h; regioselective reaction;
DOI:10.1021/jo501739j

Reference yield:

: 267002-56-2
4-chloro-2-(prop-2-en-1-yl)aniline

: 1251443-45-4
5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

2: 2-iodo-propane; manganese(IV) oxide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / α,α,α-trifluorotoluene / 16 h / 120 °C / Inert atmosphere; Molecular sieve

With pyridine; 2-iodo-propane; manganese(IV) oxide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In dichloromethane; α,α,α-trifluorotoluene;
DOI:10.1002/anie.201109044

Reference yield:

: 13519-80-7
N-allyl-4-chloroaniline

: 1251443-45-4
5-chloro-2-(iodomethyl)-1-(4-methylbenzene-1-sulfonyl)-2,3-dihydro-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / -78 °C / Inert atmosphere

1.2: 5.5 h / 180 °C / Inert atmosphere

2.1: pyridine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3.1: 2-iodo-propane; manganese(IV) oxide; copper(II) bis(trifluoromethanesulfonate); potassium carbonate / α,α,α-trifluorotoluene / 16 h / 120 °C / Inert atmosphere; Molecular sieve

With pyridine; 2-iodo-propane; manganese(IV) oxide; boron trifluoride diethyl etherate; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; In dichloromethane; α,α,α-trifluorotoluene;
DOI:10.1002/anie.201109044