7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

Base Information

Chemical Name:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile
CAS No.:168542-77-6
Molecular Formula:C₁₇H₁₃N₃O
Molecular Weight:275.31
Hs Code.:

Synonyms:7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

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Chemical Property of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

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Technology Process of 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

There total 6 articles about 7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 168542-76-5
N-(cyanomethyl)-N-methyl-3-(4-methylbenzoyl)-2-pyridinecarboxamide

: 168542-77-6
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 4h; Heating;
DOI:10.1021/jm00016a014

Reference yield:

: 699-98-9
Pyridine-2,3-dicarboxylic anhydride

: 168542-77-6
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / AlCl₃ / 4 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

3: Et₃N / tetrahydrofuran / Heating

4: 56 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 4 h / Heating

With aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;
DOI:10.1021/jm00016a014

Reference yield:

: 116060-91-4
3-(4-methylbenzoyl)-2-pyridine carboxylic acid

: 168542-77-6
7,8-dihydro-7-methyl-5-(4-methylphenyl)-8-oxo-6-pyrido<3,4-b>pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂, DMF / tetrahydrofuran / 3.5 h / Heating

2: Et₃N / tetrahydrofuran / Heating

3: 56 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / toluene / 4 h / Heating

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; toluene;
DOI:10.1021/jm00016a014