methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

Base Information

Chemical Name:methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate
CAS No.:1375459-46-3
Molecular Formula:C₂₄H₂₃ClN₂O₃S
Molecular Weight:454.977
Hs Code.:

Synonyms:methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

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Chemical Property of methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

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Technology Process of methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

There total 3 articles about methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1387635-24-6
methyl 5-(3-(chlorocarbonyl)pyridin-2-ylthio)pentanoate

: 1204-44-0
2-(4-chlorophenyl)aniline

: 1375459-46-3
methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1016/j.foodchem.2012.04.090

Reference yield:

: 1375459-44-1
2-(4-carboxybutylthio)nicotinic acid

: 1375459-46-3
methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; chloro-trimethyl-silane / 168 h / 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C

3: pyridine; dmap / dichloromethane / 72 h / 20 °C

With pyridine; methanol; dmap; chloro-trimethyl-silane; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.foodchem.2012.04.090

Reference yield:

: 2067-33-6
5-bromopentanoic acid

: 1375459-46-3
methyl 5-((3-((4'-chloro-[1,1'-biphenyl]-2-yl)carbamoyl)pyridin-2-yl)thio)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / water

1.2: 4 h / 60 °C

1.3: pH 2 - 3 / Cooling with ice

2.1: methanol; chloro-trimethyl-silane / 168 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 24 h / 20 °C

4.1: pyridine; dmap / dichloromethane / 72 h / 20 °C

With pyridine; methanol; dmap; chloro-trimethyl-silane; oxalyl dichloride; sodium hydrogencarbonate; N,N-dimethyl-formamide; In dichloromethane; water;
DOI:10.1016/j.foodchem.2012.04.090