ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Base Information

Chemical Name:ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate
CAS No.:165179-94-2
Molecular Formula:C₂₁H₂₉F₂NO₇
Molecular Weight:445.461
Hs Code.:

Synonyms:ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

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Technology Process of ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

There total 3 articles about ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 107-30-2
chloromethyl methyl ether

: 165179-93-1
ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

: 165179-94-2
ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm970728z

Reference yield:

: 152835-78-4
ethyl 3,5-difluoro-6-(N-pivaloylamino)-2-(2-tetrahydropyranyloxy)benzoate

: 165179-94-2
ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2) trimethylborate, 3.) AcOH, 30percent aq. H₂O₂

2: 93 percent / iPr₂NEt, / CH₂Cl₂ / 0.5 h / Ambient temperature

With Trimethyl borate; dihydrogen peroxide; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm970728z

Reference yield:

: 152835-84-2
ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate

: 165179-94-2
ethyl 3,5-difluoro-4-methoxymethoxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

2: 1.) LDA, 2) trimethylborate, 3.) AcOH, 30percent aq. H₂O₂

3: 93 percent / iPr₂NEt, / CH₂Cl₂ / 0.5 h / Ambient temperature

With Trimethyl borate; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm970728z