ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Base Information

Chemical Name:ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate
CAS No.:165179-93-1
Molecular Formula:C₁₉H₂₅F₂NO₆
Molecular Weight:401.407
Hs Code.:

Synonyms:ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

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Technology Process of ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

There total 4 articles about ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 121-43-7,63156-11-6
Trimethyl borate

: sodium hydrogensulfite

: 152835-78-4
ethyl 3,5-difluoro-6-(N-pivaloylamino)-2-(2-tetrahydropyranyloxy)benzoate

: 165179-93-1
ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:: With hydrogenchloride; n-butyllithium; sodium chloride; dihydrogen peroxide; acetic acid; diisopropylamine; In tetrahydrofuran; hexane;

Reference yield: 54.0%

: 165179-93-1
ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:

Reference yield:

: 152835-84-2
ethyl 3,5-difluoro-6-pivaloylamino-2-(2-tetrahydropyranyloxy)-4-trimethylsilylbenzoate

: 165179-93-1
ethyl 3,5-difluoro-4-hydroxy-6-pivaloylamino-2-(2-tetrahydropyranyloxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

2: 1.) LDA, 2) trimethylborate, 3.) AcOH, 30percent aq. H₂O₂

With Trimethyl borate; tetrabutyl ammonium fluoride; dihydrogen peroxide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jm970728z