Technology Process of 2-(azidomethyl)-1-tosylindoline
There total 4 articles about 2-(azidomethyl)-1-tosylindoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide; copper(II) 2-ethylhexanoate; caesium carbonate;
In
α,α,α-trifluorotoluene;
at 120 ℃;
for 24h;
DOI:10.1002/anie.201003499
- Guidance literature:
-
Multi-step reaction with 3 steps
1: boron trifluoride diethyl etherate / 5,5-dimethyl-1,3-cyclohexadiene / 4.17 h / 25 - 180 °C / Sealed tube
2: pyridine / dichloromethane / 30 h / 0 - 25 °C
3: sodium azide; dihydrogen peroxide; dichloro bis(acetonitrile) palladium(II) / water; tetrahydrofuran / 48 h / 25 °C
With
pyridine; dichloro bis(acetonitrile) palladium(II); sodium azide; boron trifluoride diethyl etherate; dihydrogen peroxide;
In
tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water;
DOI:10.1021/acs.orglett.0c00010
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / Reflux
2: boron trifluoride diethyl etherate / 5,5-dimethyl-1,3-cyclohexadiene / 4.17 h / 25 - 180 °C / Sealed tube
3: pyridine / dichloromethane / 30 h / 0 - 25 °C
4: sodium azide; dihydrogen peroxide; dichloro bis(acetonitrile) palladium(II) / water; tetrahydrofuran / 48 h / 25 °C
With
pyridine; dichloro bis(acetonitrile) palladium(II); sodium azide; boron trifluoride diethyl etherate; dihydrogen peroxide; potassium carbonate;
In
tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.orglett.0c00010
