ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

Base Information

Chemical Name:ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate
CAS No.:405200-61-5
Molecular Formula:C₁₉H₃₄O₅
Molecular Weight:342.476
Hs Code.:

Synonyms:ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

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Chemical Property of ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

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Technology Process of ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

There total 5 articles about ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 141-78-6
ethyl acetate

: 197460-72-3
ethyl 5-(3,3-dimethyl-2-oxocyclohexyl)pentanoate

: 405200-61-5
ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

Guidance literature:: ethyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.5h;

ethyl 5-(3,3-dimethyl-2-oxocyclohexyl)pentanoate; In tetrahydrofuran; hexane; at -70 ℃; for 2h;
DOI:10.1039/b104394n

Reference yield:

: 14660-52-7
ethyl 5-bromovalerate

: 405200-61-5
ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.25 h / 20 °C

1.2: 70 percent / tetrahydrofuran; dimethylformamide / 18 h / Heating

2.1: aq. HCl / 18 h / Heating

3.1: 9.7 g / H₂SO₄ / 20 h / Heating

4.1: LDA / tetrahydrofuran; hexane / 0.5 h / -70 °C

4.2: 91 percent / tetrahydrofuran; hexane / 2 h / -70 °C

With hydrogenchloride; sulfuric acid; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b104394n

Reference yield:

: 101327-97-3
Methyl 3,3-dimethyl-2-oxocyclohexanecarboxylate

: 405200-61-5
ethyl 5-(2-ethoxycarbonylmethyl-2-hydroxy-3,3-dimethylcyclohexyl)pentanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.25 h / 20 °C

1.2: 70 percent / tetrahydrofuran; dimethylformamide / 18 h / Heating

2.1: aq. HCl / 18 h / Heating

3.1: 9.7 g / H₂SO₄ / 20 h / Heating

4.1: LDA / tetrahydrofuran; hexane / 0.5 h / -70 °C

4.2: 91 percent / tetrahydrofuran; hexane / 2 h / -70 °C

With hydrogenchloride; sulfuric acid; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b104394n