(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate

Base Information

• Chemical Name: (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate
• CAS No.: 1353754-79-6
• Molecular Formula: C₁₃H₁₁IN₄O₅
• Molecular Weight: 430.159
• Mol file: 1353754-79-6.mol

Synonyms:(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate

Chemical Property of (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate

There total 1 articles about (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol (187235-08-1) + 1-iodo-4-isocyanatobenzene (15845-62-2) → (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate (1353754-79-6)

Guidance literature:

With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm2012276

Reference yield: 64.0%

(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate (1353754-79-6) + (6-fluoropyridin-3-yl)boronic acid (351019-18-6) → C18H14FN5O5 (1353754-65-0)

Guidance literature:

(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate; (6-fluoropyridin-3-yl)boronic acid; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/jm2012276

Reference yield: 56.0%

6-(trifluoromethyl)-3-pyridinylboronic acid (868662-36-6) + (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate (1353754-79-6) → (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl {4-[6-(trifluoromethyl)pyridin-3-yl]phenyl}carbamate (1353754-64-9)

Guidance literature:

6-(trifluoromethyl)-3-pyridinylboronic acid; (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl (4-iodophenyl)carbamate; With potassium carbonate; In ethanol; toluene; for 0.0833333h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; toluene; for 1h; Inert atmosphere; Reflux;

DOI:10.1021/jm2012276

upstream raw materials:

(S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐ol

1-iodo-4-isocyanatobenzene

Downstream raw materials:

(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl {4-[6-(trifluoromethyl)pyridin-3-yl]phenyl}carbamate

(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl {4-[2-(trifluoromethyl)pyridin-4-yl]phenyl}carbamate

C₁₈H₁₄FN₅O₅