[4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester
• CAS No.: 852998-12-0
• Molecular Formula: C₂₆H₃₃F₂N₃O₆
• Molecular Weight: 521.561

Synonyms:[4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

Chemical Property of [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

There total 4 articles about [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(4-butoxy-6-tert-butoxycarbonylamino-pyridin-2-yl)-carbamic acid tert-butyl ester (852998-11-9) + 2,6-difluorobenzoylchloride (18063-02-0) → [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (852998-12-0)

Guidance literature:

(4-butoxy-6-tert-butoxycarbonylamino-pyridin-2-yl)-carbamic acid tert-butyl ester; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In various solvent(s); at -15 - 0 ℃; for 16h;

2,6-difluorobenzoylchloride; In various solvent(s); at 0 ℃; for 3h;

DOI:10.1016/j.bmcl.2005.03.024

Reference yield:

4-butoxy-pyridine-2,6-dicarbonyl diazide → [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (852998-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Heating

2.1: n-BuLi; (N,N,N',N'-tetramethyl)ethylenediamine / various solvent(s) / 16 h / -15 - 0 °C

2.2: 37 percent / various solvent(s) / 3 h / 0 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In various solvent(s);

DOI:10.1016/j.bmcl.2005.03.024

Reference yield:

4-Butoxypyridin-2,6-dicarbonsaeuredihydrazid (6485-03-6) → [4-butoxy-6-tert-butoxycarbonylamino-5-(2,6-difluoro-benzoyl)-pyridin-2-yl]-carbamic acid tert-butyl ester (852998-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaNO₂; HCl / 1 h / 0 °C

2.1: Heating

3.1: n-BuLi; (N,N,N',N'-tetramethyl)ethylenediamine / various solvent(s) / 16 h / -15 - 0 °C

3.2: 37 percent / various solvent(s) / 3 h / 0 °C

With hydrogenchloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium nitrite; In various solvent(s);

DOI:10.1016/j.bmcl.2005.03.024

upstream raw materials:

(4-butoxy-6-tert-butoxycarbonylamino-pyridin-2-yl)-carbamic acid tert-butyl ester

2,6-difluorobenzoylchloride

4-Butoxypyridin-2,6-dicarbonsaeuredihydrazid

dibutyl 4-butoxypyridine-2,6-dicarboxylate

Downstream raw materials:

(2,6-diamino-4-butoxy-pyridin-3-yl)-(2,6-difluoro-phenyl)-methanone

C₂₇H₃₀F₂N₄O₆S

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