2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

Base Information

Chemical Name:2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran
CAS No.:554427-65-5
Molecular Formula:C₁₉H₂₆O₄
Molecular Weight:318.413
Hs Code.:

Synonyms:2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

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Chemical Property of 2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

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Technology Process of 2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

There total 8 articles about 2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1779-49-3
Methyltriphenylphosphonium bromide

: 554427-61-1
C₃₁H₃₈O₁₀S₂

: 554427-65-5
2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

Guidance literature:: Methyltriphenylphosphonium bromide; With phenyllithium; In tetrahydrofuran; at 20 ℃; for 0.5h;

C₃₁H₃₈O₁₀S₂; In tetrahydrofuran; for 16h; Heating;

formaldehyd; With phenyllithium; In tetrahydrofuran; for 1h;
DOI:10.1016/S0040-4039(03)00565-3

Reference yield: 35.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1779-49-3
Methyltriphenylphosphonium bromide

: 554427-63-3
2-[(1S,2S)-3-Iodo-1-iodomethyl-2-(4-methoxy-benzyloxy)-propoxy]-tetrahydro-pyran

: 554427-65-5
2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

Guidance literature:: Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; at 66 ℃; for 0.5h;

2-[(1S,2S)-3-Iodo-1-iodomethyl-2-(4-methoxy-benzyloxy)-propoxy]-tetrahydro-pyran; In tetrahydrofuran; for 16h; Heating;

formaldehyd; With n-butyllithium; In tetrahydrofuran; for 1h;
DOI:10.1016/S0040-4039(03)00565-3

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 554427-65-5
2-[(1R,2R)-2-(4-Methoxy-benzyloxy)-4-methylene-cyclopentyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / PPTS / CH₂Cl₂

2.1: nBuLi / tetrahydrofuran / 0.5 h / 66 °C

2.2: tetrahydrofuran / 16 h / Heating

2.3: 35 percent / nBuLi / tetrahydrofuran / 1 h

With n-butyllithium; pyridinium p-toluenesulfonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(03)00565-3