2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

Base Information

Chemical Name:2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester
CAS No.:1609531-41-0
Molecular Formula:C₂₀H₂₄ClN₅O₅
Molecular Weight:449.894
Hs Code.:

Synonyms:2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

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Chemical Property of 2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

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Technology Process of 2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

There total 3 articles about 2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 870-46-2
t-butoxycarbonylhydrazine

: 1609531-36-3
3-((2-chloro-5-(methylaminylcarboxyl)pyridin-4-yl)amino)-2-methoxybenzoic acid

: 1609531-41-0
2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 0.5h;

Reference yield:

: 73027-79-9
4,6-dichloro-nicotinic acid

: 1609531-41-0
2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / chloroform / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 0.5 h / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With oxalyl dichloride; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; chloroform; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: 1609531-41-0
2-(3-((2-chloro-5-(methylaminoformyl)pyridin-4-yl)amino)-2-methoxybenzoyl)hydrazinylformic acid tert butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl acetamide / 0.5 h / 20 °C

2: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;