(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

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Chemical Name:(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol
CAS No.:1416956-57-4
Molecular Formula:C₁₇H₁₅BrCl₂N₂O₄S
Molecular Weight:494.193
Hs Code.:

Synonyms:(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

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Chemical Property of (3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

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Technology Process of (3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

There total 8 articles about (3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1416956-56-3
methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

: 1416956-57-4
(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 ℃; for 10.5h;
DOI:10.1039/c2cc37110c

Reference yield:

: 1416956-54-1
methyl 3-bromo-4,5-dichloro-1-(3-methoxy-2-methylidene-3-oxo-propyl)-1H-pyrrole-2-carboxylate

: 1416956-57-4
(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: ozone; oxygen / dichloromethane / 0.3 h / -78 °C

1.2: 6.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / -42 °C

2.2: -42 - 20 °C

3.1: toluene / 16 h / Reflux

4.1: ozone; oxygen / methanol; dichloromethane / 0.2 h / -78 °C

4.2: 14 h

5.1: ammonium acetate; acetic acid / 0.5 h

6.1: dmap; N-ethyl-N,N-diisopropylamine / 24 h / Cooling

7.1: diisobutylaluminium hydride / toluene; dichloromethane / 10.5 h / 0 °C

With dmap; ammonium acetate; oxygen; sodium hydride; diisobutylaluminium hydride; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c2cc37110c

Reference yield:

: 1416956-52-9
methyl 3-bromo-4,5-dichloro-1-(1-methoxy-1,2,5-trioxopentan-3-yl)-1H-pyrrole-2-carboxylate

: 1416956-57-4
(3-bromo-4,5-dichloro-1-[2-(hydroxymethyl)-1-[(4-methylbenzene)-sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrol-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate; acetic acid / 0.5 h

2: dmap; N-ethyl-N,N-diisopropylamine / 24 h / Cooling

3: diisobutylaluminium hydride / toluene; dichloromethane / 10.5 h / 0 °C

With dmap; ammonium acetate; diisobutylaluminium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene;
DOI:10.1039/c2cc37110c