methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate
CAS No.:1416956-56-3
Molecular Formula:C₁₉H₁₅BrCl₂N₂O₆S
Molecular Weight:550.214
Hs Code.:

Synonyms:methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

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Technology Process of methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

There total 7 articles about methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1416956-53-0
methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

: 98-59-9
p-toluenesulfonyl chloride

: 1416956-56-3
methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; for 24h; Cooling;
DOI:10.1039/c2cc37110c

Reference yield:

: 1416956-54-1
methyl 3-bromo-4,5-dichloro-1-(3-methoxy-2-methylidene-3-oxo-propyl)-1H-pyrrole-2-carboxylate

: 1416956-56-3
methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ozone; oxygen / dichloromethane / 0.3 h / -78 °C

1.2: 6.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / -42 °C

2.2: -42 - 20 °C

3.1: toluene / 16 h / Reflux

4.1: ozone; oxygen / methanol; dichloromethane / 0.2 h / -78 °C

4.2: 14 h

5.1: ammonium acetate; acetic acid / 0.5 h

6.1: dmap; N-ethyl-N,N-diisopropylamine / 24 h / Cooling

With dmap; ammonium acetate; oxygen; sodium hydride; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c2cc37110c

Reference yield:

: 1416956-50-7
methyl 3-bromo-4,5-dichloro-1-(3-methoxy-2,3-dioxopropyl)-1H-pyrrole-2-carboxylate

: 1416956-56-3
methyl 3-bromo-4,5-dichloro-1-[2-(methoxycarbonyl)-1-[(4-methyl-benzene)sulfonyl]-1H-pyrrol-3-yl]-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / -42 °C

1.2: -42 - 20 °C

2.1: toluene / 16 h / Reflux

3.1: ozone; oxygen / methanol; dichloromethane / 0.2 h / -78 °C

3.2: 14 h

4.1: ammonium acetate; acetic acid / 0.5 h

5.1: dmap; N-ethyl-N,N-diisopropylamine / 24 h / Cooling

With dmap; ammonium acetate; oxygen; sodium hydride; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1039/c2cc37110c