O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

Base Information

Chemical Name:O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate
CAS No.:1256839-66-3
Molecular Formula:C₂₂H₁₈FN₃O₂S
Molecular Weight:407.468
Hs Code.:

Synonyms:O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

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Chemical Property of O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

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Technology Process of O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

There total 4 articles about O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.5%

: 1256839-64-1
7-(4-fluorophenyl)-5-p-tolyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-thione

: 541-41-3
chloroformic acid ethyl ester

: 1256839-66-3
O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

Guidance literature:: With potassium hydroxide; In water; benzene; at 25 ℃; for 4h;
DOI:10.1135/cccc2009566

Reference yield:

: 1256839-49-2
2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile

: 1256839-66-3
O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

Guidance literature:: Multi-step reaction with 4 steps

1: 3 h / Reflux

2: trichlorophosphate / 3 h / Reflux

3: thiourea / ethanol / 2 h / Reflux

4: potassium hydroxide / water; benzene / 4 h / 25 °C

With thiourea; potassium hydroxide; trichlorophosphate; In ethanol; water; benzene;
DOI:10.1135/cccc2009566

Reference yield:

: 1256839-60-7
7-(4-fluorophenyl)-5-p-tolyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

: 1256839-66-3
O-ethyl S-7-(4-fluorophenyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylcarbonothioate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: thiourea / ethanol / 2 h / Reflux

3: potassium hydroxide / water; benzene / 4 h / 25 °C

With thiourea; potassium hydroxide; trichlorophosphate; In ethanol; water; benzene;
DOI:10.1135/cccc2009566