2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile

Base Information

• Chemical Name: 2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile
• CAS No.: 1256839-49-2
• Molecular Formula: C₁₈H₁₄FN₃
• Molecular Weight: 291.328
• Mol file: 1256839-49-2.mol

Synonyms:2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile

Chemical Property of 2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile

There total 1 articles about 2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-fluorophenylamino)-1-p-tolylethan-1-one (146537-26-0) + malononitrile (109-77-3) → 2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile (1256839-49-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 3h; Reflux;

DOI:10.1135/cccc2009566

Reference yield: 92.9%

2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile (1256839-49-2) + benzaldehyde (100-52-7) → 2-(benzylideneamino)-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile (1256839-56-1)

Guidance literature:

With potassium hydroxide; In ethanol; for 0.25h; Heating;

DOI:10.1135/cccc2009566

Reference yield: 86.0%

2-amino-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrole-3-carbonitrile (1256839-49-2) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(3-cyano-1-(4-fluorophenyl)-4-p-tolyl-1H-pyrrol-2-yl)acetamide (1256839-50-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 5h;

DOI:10.1135/cccc2009566

upstream raw materials:

2-(4-fluorophenylamino)-1-p-tolylethan-1-one

malononitrile

Downstream raw materials:

(4-fluorophenyl)-2-(thiophen-2-ylmethyleneamino)-4-p-tolyl-1H-pyrrole-3-carbonitrile

7-(4-fluorophenyl)-5-p-tolyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one

C₂₀H₁₈FN₄⁽¹⁺⁾*I^(1-)

C₂₁H₂₀FN₄⁽¹⁺⁾*I^(1-)