Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI)
• CAS No.: 397274-64-5
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.155
• Mol file: 397274-64-5.mol

Synonyms:Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI)

Chemical Property of Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI)

There total 17 articles about Cyclopropanecarboxaldehyde, 2-[(acetyloxy)methyl]-, (1S,2R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.1%

(1S,2R)-2-(hydroxymethyl)cyclopropane-1-methyl acetate (123809-77-8) → (1R,2S)-2-acetoxymethyl-1-formylcyclopropane (166762-22-7,397274-64-5)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -50 ℃; for 0.25h;

DOI:10.1002/hlca.19920750309

Reference yield: 62.0%

(4R,5R)-diisopropyl 2-((1R,2R)-2-(acetoxymethyl)cyclopropyl)-1,3-dioxolane-4,5-dicarboxylate → ((1R,2R)-2-formylcyclopropyl)methyl acetate (1410809-78-7,397274-64-5)

Guidance literature:

With acetic acid; at 80 ℃; for 2h;

Reference yield: 62.0%

(4R,5R)-diisopropyl 2-((1S,2R)-2-(acetoxymethyl)cyclopropyl)-1,3-dioxolane-4,5-dicarboxylate → ((1R,2R)-2-formylcyclopropyl)methyl acetate (1410809-78-7,397274-64-5)

Guidance literature:

With acetic acid; at 80 ℃; for 2h;

DOI:10.1002/cmdc.201900287

upstream raw materials:

(1S,2R)-2-(hydroxymethyl)cyclopropane-1-methyl acetate

Acetic acid (1R,2S)-2-hydroxymethyl-cyclopropylmethyl ester

((1R,2S)-2-Hydroxymethyl-cyclopropyl)-methanol

acetic acid trans-4-oxo-but-2-enyl ester

Downstream raw materials:

(6S)-6-<(1E)-but-1-enyl>cyclohepta-1,4-diene

N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide

4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzoic acid

N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide