tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate
CAS No.:1519044-07-5
Molecular Formula:C₂₃H₂₄Cl₂N₂O₅S₂
Molecular Weight:543.492
Hs Code.:

Synonyms:tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

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Chemical Property of tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

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Technology Process of tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

There total 4 articles about tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 163517-60-0
2-(2,4-dichlorophenoxy)phenylboronic acid

: 1519044-06-4
tert-butyl 2-(3-bromothiophene-2-sulfonamido)ethylcarbamate

: 1519044-07-5
tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In tetrahydrofuran; for 8h; Inert atmosphere; Reflux;
DOI:10.1002/cmdc.201400058

Reference yield:

: 26306-64-9
2,4-dichloro-1-(2-aminophenoxy)benzene

: 1519044-07-5
tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / water / 0.17 h / 0 - 5 °C

1.2: 4.5 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

2.3: 20 °C

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; n-butyllithium; sulfuric acid; palladium diacetate; sodium nitrite; In tetrahydrofuran; water; 3.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058

Reference yield:

: 175136-78-4
2,4-dichloro-1-(2-iodophenoxy)benzene

: 1519044-07-5
tert-butyl 2-(3-(2-(2,4-dichlorophenoxy)phenyl)thiophene-2-sulfonamido)ethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

1.3: 20 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; n-butyllithium; palladium diacetate; In tetrahydrofuran; 2.1: |Suzuki Coupling;
DOI:10.1002/cmdc.201400058