(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

Base Information

Chemical Name:(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide
CAS No.:1584713-98-3
Molecular Formula:C₂₉H₃₀ClF₃N₄O₃
Molecular Weight:575.03
Hs Code.:

(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

Synonyms:(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

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Chemical Property of (2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

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Technology Process of (2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

There total 20 articles about (2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.2%

: 1584715-43-4
(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

: 1584713-98-3
(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; isopropyl alcohol; for 3.5h; Inert atmosphere;

Reference yield:

: 1584715-37-6
9-bromo-5-(4-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584713-98-3
(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 16 h / 20 °C

3.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

4.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

6.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / tetrahydrofuran; isopropyl alcohol / 3.5 h / Inert atmosphere

With potassium phosphate; trifluorormethanesulfonic acid; ammonia; palladium diacetate; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584713-98-3
(2R,3S)-N-((3S)-5-( 4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

2.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

4.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ammonia / tetrahydrofuran; isopropyl alcohol / 3.5 h / Inert atmosphere

With potassium phosphate; trifluorormethanesulfonic acid; ammonia; palladium diacetate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic acid; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene;