(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

Base Information

Chemical Name:(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid
CAS No.:1584715-43-4
Molecular Formula:C₂₉H₂₉ClF₃N₃O₄
Molecular Weight:576.015
Hs Code.:

(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

Synonyms:(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

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Chemical Property of (2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

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Technology Process of (2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

There total 19 articles about (2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.2%

: 1584715-89-8
(2S,3R)-tert-butyl 3-((3S)-(5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4 ]diazepin-3-yl)carbamoyl)-2-( cyclopropylmethyl)-6,6,6-trifluorohexanoate

: 1584715-43-4
(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1584715-37-6
9-bromo-5-(4-chlorophenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-43-4
(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

2.2: 2 h / -78 °C

2.3: 16 h / 20 °C

3.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

4.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

6.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium phosphate; trifluorormethanesulfonic acid; palladium diacetate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1584715-39-8
3-azido-9-bromo-5-(4-chlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1584715-43-4
(2S,3R)-3-(((3S)-5-(4-chlorophenyl)-9-cyclopropyl-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine / tetrahydrofuran; water / 3 h / 20 °C

2.1: trifluoroacetic acid; methoxybenzene; trifluorormethanesulfonic acid / 16 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: palladium diacetate; potassium phosphate; tricyclohexylphosphine / toluene; water / 5 h / 90 - 100 °C / Inert atmosphere

4.2: CHIRALPAK? IA / Supercritical conditions; liquid CO2

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With potassium phosphate; trifluorormethanesulfonic acid; palladium diacetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; triethylamine; triphenylphosphine; trifluoroacetic acid; tricyclohexylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;