4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Base Information

Chemical Name:4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid
CAS No.:1026501-11-0
Molecular Formula:C₁₉H₂₃N₃O₃S
Molecular Weight:373.476
Hs Code.:

Synonyms:4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Suppliers and Price of 4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

There total 3 articles about 4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 586-89-0
4-acetyl-benzoic acid

: 1026501-11-0
4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / Br₂; AcOH / 1 h / 80 °C

2: tetrahydrofuran / 3 h / Heating

With bromine; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm058198r

Reference yield:

: 398137-19-4
1-(tetrahydro-2H-pyran-4-yl)piperazine

: 1026501-11-0
4-{2-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-thiazol-4-yl}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 2 h / 20 - 55 °C

1.2: NH₃ / ethanol; tetrahydrofuran / 20 - 55 °C

2.1: tetrahydrofuran / 3 h / Heating

In tetrahydrofuran;
DOI:10.1021/jm058198r