t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

Base Information

Chemical Name:t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate
CAS No.:102208-40-2
Molecular Formula:C₂₉H₃₈N₂O₅S
Molecular Weight:526.697
Hs Code.:

Synonyms:t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

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Chemical Property of t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

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Technology Process of t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

There total 7 articles about t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 110267-58-8
(S)-2-((3R,6R)-5-Oxo-3-phenyl-[1,4]thiazepan-6-ylamino)-4-phenyl-butyric acid ethyl ester

: 102208-40-2
t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jm00394a009

Reference yield:

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 102208-40-2
t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

3: 100 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With pyridine; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00394a009

Reference yield:

: 1914-59-6
(E)-2-oxo-4-phenyl-3-butenoic acid

: 102208-40-2
t-butyl α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxo-3(R)-phenylperhydro-1,4-thiazepin-4-yl}acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / p-toluenesulfonic acid*H₂O / benzene / 5 h / Heating

2: 29 percent / H₂ / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr

3: 86 percent / KOH / ethanol / 16 h / Ambient temperature

4: 98 percent / conc. H₂SO₄ / 16 h / Ambient temperature

5: 100 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

6: 100 percent / Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

7: 100 percent / NaH / dimethylformamide / 5 h / Ambient temperature

With pyridine; potassium hydroxide; sulfuric acid; hydrogen; sodium hydride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; benzene;
DOI:10.1021/jm00394a009