N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

Base Information

Chemical Name:N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide
CAS No.:1312473-93-0
Molecular Formula:C₁₈H₂₂N₂O₅S
Molecular Weight:378.449
Hs Code.:

Synonyms:N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

Chemical Property:

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Technology Process of N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

There total 7 articles about N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312479-38-1
2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

: 1312473-93-0
N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 - 25 ℃; for 0.25h;

Reference yield:

: 153034-80-1
2-Fluoro-4-iodo-3-methylpyridine

: 1312473-93-0
N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride; water / 1,4-dioxane / 1 h / 100 °C

2: caesium carbonate / tetrahydrofuran / 20 - 50 °C

3: potassium carbonate / PD EnCat_.(TM). / 1,4-dioxane; water / 20 - 80 °C

4: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 - 25 °C

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 - 25 °C

6: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.25 h / 20 - 25 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; PD EnCat; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1312473-93-0
N-hydroxy-2-methyl-4-(3-methyl-2-oxo-4-phenylpyridin-1(2H)-yl)-2-(methylsulfonyl)butanamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrahydrofuran / 20 - 50 °C

2: potassium carbonate / PD EnCat_.(TM). / 1,4-dioxane; water / 20 - 80 °C

3: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 20 - 25 °C

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 - 25 °C

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 0.25 h / 20 - 25 °C

With hydrogenchloride; lithium hydroxide monohydrate; water; potassium carbonate; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; PD EnCat; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;