2-FLUORO-4-IODO-3-PICOLINE

Base Information

• Chemical Name: 2-FLUORO-4-IODO-3-PICOLINE
• CAS No.: 153034-80-1
• Molecular Formula: C6H5FIN
• Molecular Weight: 237.015
• Hs Code.: 2933399090
• Mol file: 153034-80-1.mol

Synonyms:2-Fluor-4-iod-3-methylpyridin;

Chemical Property of 2-FLUORO-4-IODO-3-PICOLINE

Chemical Property:

• Vapor Pressure: 0.05mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 243.507 °C at 760 mmHg
• PKA: -1.53±0.18(Predicted)
• Flash Point: 101.07 °C
• PSA: 12.89000
• Density: 1.893 g/cm³
• LogP: 2.13370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-iodo-3-picoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-FLUORO-4-IODO-3-PICOLINE

There total 4 articles about 2-FLUORO-4-IODO-3-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-fluoro-3-iodopyridine (113975-22-7) + methyl iodide (74-88-4) → 2-Fluoro-4-iodo-3-methylpyridine (153034-80-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; 1.) -75 deg C, 1 h, 2.) -75 deg C, 2 h;

DOI:10.1021/jo00079a031

Reference yield:

2-fluoropyridine (372-48-5) + methyl iodide (74-88-4) → 2-Fluoro-4-iodo-3-methylpyridine (153034-80-1)

Guidance literature:

2-fluoropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.666667h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at -70 ℃; for 2.5h;

methyl iodide; In tetrahydrofuran; hexane; at -70 ℃; for 3h;

Reference yield:

2-fluoro-4-iodopyridine (22282-70-8) + methyl iodide (74-88-4) → 2-Fluoro-4-iodo-3-methylpyridine (153034-80-1)

Guidance literature:

2-fluoro-4-iodopyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

upstream raw materials:

2-fluoro-3-iodopyridine

methyl iodide

2-fluoro-4-iodopyridine

2-fluoropyridine

Refernces

• 1、 -. "HYDROXYMETHYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS". Page/Page column 35. . Retrieved 2016/06/28.
• 2、 -. "HETEROCYCLIC COMPOUND". Paragraph 0495; 0496. . Retrieved 2015/05/05.