N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

Base Information

Chemical Name:N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide
CAS No.:1152131-94-6
Molecular Formula:C₃₆H₂₉ClFN₅O₂
Molecular Weight:618.11
Hs Code.:

Synonyms:N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

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Chemical Property of N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

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Technology Process of N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

There total 5 articles about N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1152131-93-5
(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

: 1152131-94-6
N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

Guidance literature:: With platinum(IV) oxide; hydrogen; In tetrahydrofuran; for 12h; under 7500.75 Torr; chemoselective reaction;
DOI:10.1021/jm100665z

Reference yield:

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

: 1152131-94-6
N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.5 h / 20 °C / Inert atmosphere

1.2: pH 7 / Inert atmosphere

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 20 °C / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 7500.75 Torr

With platinum(IV) oxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm100665z

Reference yield:

: C₄₁H₃₅ClFN₅O₄

: 1152131-94-6
N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 20 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 7500.75 Torr

With platinum(IV) oxide; hydrogen; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1021/jm100665z