(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

Base Information

Chemical Name:(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide
CAS No.:1152131-93-5
Molecular Formula:C₃₆H₂₇ClFN₅O₂
Molecular Weight:616.094
Hs Code.:

Synonyms:(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

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Chemical Property of (E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

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Technology Process of (E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

There total 5 articles about (E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1152131-93-5
(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

Guidance literature:

Reference yield:

: C₄₁H₃₅ClFN₅O₄

: 1152131-93-5
(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

Guidance literature:: With trifluoroacetic acid; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm100665z

Reference yield:

: 1152131-78-6
3-[4-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}phenyl]acrylic acid tert-butyl ester

: 1152131-93-5
(E)-N-(2-aminophenyl)-3-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.5 h / 20 °C / Inert atmosphere

1.2: pH 7 / Inert atmosphere

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm100665z