4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

Base Information

Chemical Name:4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene
CAS No.:1360569-06-7
Molecular Formula:C₁₉H₁₇BrF₄O
Molecular Weight:417.241
Hs Code.:

Synonyms:4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

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Chemical Property of 4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

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Technology Process of 4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

There total 7 articles about 4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

: 1038404-00-0
(1-(trifluoromethyl)cyclobutyl)methyl 4-methylbenzenesulfonate

: 1210344-13-0
4-(5-bromo-2-fluorobenzyl)phenol

: 1360569-06-7
4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 6h; Inert atmosphere;

Reference yield:

: 588-96-5
4-bromoethoxybenzene

: 1360569-06-7
4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: magnesium / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 12 h / 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

4: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; boron tribromide; caesium carbonate; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1360569-06-7
4-bromo-1-fluoro-2-(4-((1-(trifluoromethyl)cyclobutyl)methoxy)benzyl)benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 10 h / Reflux

2.1: magnesium / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.1: triethylsilane; boron trifluoride diethyl etherate / diethyl ether; dichloromethane; acetonitrile / 12 h / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 120 °C / Inert atmosphere

With triethylsilane; boron trifluoride diethyl etherate; boron tribromide; potassium carbonate; caesium carbonate; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;