ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Base Information

Chemical Name:ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate
CAS No.:313726-95-3
Molecular Formula:C₂₀H₂₀BrNO₄S
Molecular Weight:450.353
Hs Code.:

Synonyms:ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

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Chemical Property of ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

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Technology Process of ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

There total 11 articles about ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 943819-82-7
ethyl 4-{(4-bromo-2-formylphenyl)[(4-methylphenyl)sulfonyl]amino}butanoate

: 313726-95-3
ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: With sodium ethanolate; Diethyl carbonate; In ethanol; at 20 ℃; for 3h;
DOI:10.3987/COM-07-11025

Reference yield:

: 5344-90-1
2-Aminobenzyl alcohol

: 313726-95-3
ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / pyridine / tetrahydrofuran / 1.5 h / 20 °C

2: 80 percent / MnO₂ / acetone / 15 h / 20 °C

3: 93 percent / AcONa; Br₂ / acetic acid; H₂O / 4 h / 20 °C

4: 89 percent / K₂CO₃ / dimethylformamide / 4 h / 70 °C

5: 73 percent / diethyl carbonate; EtONa / ethanol / 3 h / 20 °C

With pyridine; manganese(IV) oxide; bromine; sodium ethanolate; sodium acetate; potassium carbonate; Diethyl carbonate; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; acetone; 5: intramolecular Claisen-type condensation;
DOI:10.3987/COM-07-11025

Reference yield:

: 6590-65-4
N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

: 313726-95-3
ethyl 7-bromo-1-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-1-benzazepine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / AcONa; Br₂ / acetic acid; H₂O / 4 h / 20 °C

2: 89 percent / K₂CO₃ / dimethylformamide / 4 h / 70 °C

3: 73 percent / diethyl carbonate; EtONa / ethanol / 3 h / 20 °C

With bromine; sodium ethanolate; sodium acetate; potassium carbonate; Diethyl carbonate; In ethanol; water; acetic acid; N,N-dimethyl-formamide; 3: intramolecular Claisen-type condensation;
DOI:10.3987/COM-07-11025