(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

Base Information

Chemical Name:(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride
CAS No.:128232-04-2
Molecular Formula:C₃₂H₃₃NO₄S*ClH
Molecular Weight:564.145
Hs Code.:

Synonyms:(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

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Chemical Property of (2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

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Technology Process of (2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

There total 1 articles about (2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53338-20-8
2-aminonaphthalene-1-thiol

: 128232-03-1
(2R,3S)-3-(4-methoxyphenyl)oxirane-2-carboxylic acid (1R,2S)-2-phenylcyclohexyl ester

: 128232-04-2
(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

Guidance literature:: In toluene; for 20h; Yield given; Heating;
DOI:10.1021/jo00029a013

Reference yield: 94.5%

: 128232-04-2
(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

: 125226-69-9
(+)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; 1.) 4 h, reflux, 2.) RT, overnight;
DOI:10.1021/jo00029a013

Reference yield:

: 128232-04-2
(2R,3S)-3-<(2-amino-1-naphthalenyl)thio>-2-hydroxy-3-(4-methoxyphenyl)propanoic acid (1R,2S)-2-phenylcyclohexyl ester hydrochloride

: 125276-26-8
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 94.5 percent / 2 N NaOH / ethanol / 1.) 4 h, reflux, 2.) RT, overnight

2: 85 percent / PTSA / xylene / 19 h / Heating

With sodium hydroxide; toluene-4-sulfonic acid; In ethanol; xylene;
DOI:10.1021/jo00029a013