2-(6-Methoxynaphthalen-2-yl)propan-2-ol

Base Information

• Chemical Name: 2-(6-Methoxynaphthalen-2-yl)propan-2-ol
• CAS No.: 34352-83-5
• Molecular Formula: C₁₄H₁₆O₂
• Molecular Weight: 216.28
• European Community (EC) Number: 662-043-7
• Nikkaji Number: J1.436.834E
• Mol file: 34352-83-5.mol

Synonyms:2-(6-methoxynaphthalen-2-yl)propan-2-ol;2-(6-Methoxy-2-naphthyl)-2-propanol;34352-83-5;2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene;SCHEMBL9420901;JBFSELUOSSTETM-UHFFFAOYSA-N;AKOS024324912;CS-0272974;EN300-1838122

Chemical Property of 2-(6-Methoxynaphthalen-2-yl)propan-2-ol

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 216.115029749
• Heavy Atom Count: 16
• Complexity: 237

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC2=C(C=C1)C=C(C=C2)OC)O

Technology Process of 2-(6-Methoxynaphthalen-2-yl)propan-2-ol

There total 6 articles about 2-(6-Methoxynaphthalen-2-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-6-(1-methylethyl)naphthalene (92297-66-0) → 2-methoxy-6-(1-hydroperoxy-1-methylethyl)naphthalene + 6-methoxy-2-acetylnaphthalene (3900-45-6) + 2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene (34352-83-5)

Guidance literature:

With copper acetylacetonate; N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); In benzonitrile; at 70 ℃; for 0.833333h;

DOI:10.1007/s00706-011-0630-3

Reference yield:

2,6-diisopropylnaphthalene (24157-81-1) → 6-methoxy-2-acetylnaphthalene (3900-45-6) + 2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene (34352-83-5)

Guidance literature:

Multi-step reaction with 4 steps

1: oxygen; 1,1'-azobis(1-cyanocyclohexanenitrile) / 6 h / 105 °C

2: sulfuric acid / acetone / Heating

3: sulfuric acid / 6 h / 79 - 82 °C

4: copper acetylacetonate; N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile) / benzonitrile / 0.83 h / 70 °C

With copper acetylacetonate; N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; oxygen; 1,1'-azobis(1-cyanocyclohexanenitrile); In benzonitrile; acetone;

DOI:10.1007/s00706-011-0630-3

Reference yield:

2-hydroxy-6-(1-methylethyl)naphthalene (91909-30-7) → 6-methoxy-2-acetylnaphthalene (3900-45-6) + 2-methoxy-6-(1-hydroxy-1-methylethyl)naphthalene (34352-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 6 h / 79 - 82 °C

2: copper acetylacetonate; N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile) / benzonitrile / 0.83 h / 70 °C

With copper acetylacetonate; N-hydroxyphthalimide; 2,2'-azobis(isobutyronitrile); sulfuric acid; In benzonitrile;

DOI:10.1007/s00706-011-0630-3

upstream raw materials:

2,6-diisopropylnaphthalene

2-hydroxy-6-(1-methylethyl)naphthalene

2-methoxy-6-(1-methylethyl)naphthalene

2-(1-hydroperoxy-1-methylethyl)-6-(1-methylethyl)naphthalene

Downstream raw materials:

(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

(R)-2-(6-methoxy-2-naphthyl)propionic acid