4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester

Base Information

• Chemical Name: 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester
• CAS No.: 84454-75-1
• Molecular Formula: C₃₄H₃₅O₃P
• Molecular Weight: 522.624

Synonyms:4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester

Chemical Property of 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester

Chemical Property:

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Technology Process of 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester

There total 2 articles about 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-hexanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-hexanoic acid ethyl ester (84454-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / benzene / 1.) 10 deg C, 2.) 20 deg C, 15 min

2: 1.) THF, a) -78 deg C, 3 min, b) 0 deg C, 8 min, 2.) 25 deg C, 8 h

In benzene;

DOI:10.1021/jo00146a026

Reference yield:

ethyl iodide (75-03-6) + phenyllithium (591-51-5) + ethyl 3-oxo-2-(triphenylphosphoranylidene)-4-hexenoate (1474-30-2) → 4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-hexanoic acid ethyl ester (84454-75-1)

Guidance literature:

Yield given. Multistep reaction; 1.) THF, a) -78 deg C, 3 min, b) 0 deg C, 8 min, 2.) 25 deg C, 8 h;

DOI:10.1021/jo00146a026

Reference yield: 88.0%

4-Ethyl-3-oxo-5-phenyl-2-(triphenyl-λ5-phosphanylidene)-hexanoic acid ethyl ester (84454-75-1) → 2-Ethyl-3-phenylbutanoic acid (105401-71-6) + Triphenylphosphine oxide (791-28-6)

Guidance literature:

With sodium hydroxide; sodium hypochlorite; In tetrahydrofuran; at 25 ℃; for 40h;

DOI:10.1021/jo00153a027

upstream raw materials:

ethyl iodide

phenyllithium

ethyl 3-oxo-2-(triphenylphosphoranylidene)-4-hexenoate

ethyl (triphenylphosphoranylidene)acetate

Downstream raw materials:

ethyl 4-ethyl-3-oxo-5-phenylhexanoate

2-Ethyl-3-phenylbutanoic acid

Triphenylphosphine oxide

3-ethyl-2-phenylnonan-4-one

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