2-methoxy-4-methylisovalerophenone

Base Information

• Chemical Name: 2-methoxy-4-methylisovalerophenone
• CAS No.: 71898-88-9
• Molecular Formula: C₁₃H₁₈O₂
• Molecular Weight: 206.285
• Mol file: 71898-88-9.mol

Synonyms:2-methoxy-4-methylisovalerophenone

Chemical Property of 2-methoxy-4-methylisovalerophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4-methylisovalerophenone

There total 4 articles about 2-methoxy-4-methylisovalerophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

1-(2-hydroxy-4-methyl-phenyl)-3-methyl-butan-1-one (105337-38-0) + dimethyl sulfate (77-78-1) → 2-methoxy-4-methylisovalerophenone (71898-88-9)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Heating;

DOI:10.1246/bcsj.62.2102

Reference yield:

3-methylphenyl 3-methylbutyrate (105401-73-8) → 2-methoxy-4-methylisovalerophenone (71898-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95.3 percent / AlCl₃ / CS₂ / 1.) reflux, 2 h, 2.) 145 to 150 deg C, 4 h

2: 96.1 percent / K₂CO₃ / acetone / 10 h / Heating

With aluminium trichloride; potassium carbonate; In carbon disulfide; acetone;

DOI:10.1246/bcsj.62.2102

Reference yield:

3-methyl-phenol (108-39-4) → 2-methoxy-4-methylisovalerophenone (71898-88-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94.7 percent / benzene / 1 h / Heating

2: 95.3 percent / AlCl₃ / CS₂ / 1.) reflux, 2 h, 2.) 145 to 150 deg C, 4 h

3: 96.1 percent / K₂CO₃ / acetone / 10 h / Heating

With aluminium trichloride; potassium carbonate; In carbon disulfide; acetone; benzene;

DOI:10.1246/bcsj.62.2102

upstream raw materials:

1-(2-hydroxy-4-methyl-phenyl)-3-methyl-butan-1-one

dimethyl sulfate

3-methylphenyl 3-methylbutyrate

3-methyl-phenol

Downstream raw materials:

4-methyl-3-(2-methoxy-4-methylbenzyl)-pentanoic acid

4-methyl-3-(2-methoxy-4-methylbenzoyl)-pentanoic acid

Refernces