4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

Base Information

Chemical Name:4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine
CAS No.:1636166-71-6
Molecular Formula:C₂₀H₂₀BrN₃O₃S₂
Molecular Weight:494.433
Hs Code.:

Synonyms:4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

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Chemical Property of 4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

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Technology Process of 4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

There total 5 articles about 4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1636166-54-5
5-[1-(phenylsulfonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-thiol

: 1636166-71-6
4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

Guidance literature:: 5-[1-(phenylsulfonyl)piperidin-4-yl]-1,3,4-oxadiazol-2-thiol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

In N,N-dimethyl-formamide;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1636166-71-6
4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / water / 0.08 h / 20 °C / pH 9 - 10

2.1: hydrazine hydrate / ethanol / 20 °C / Reflux

3.1: potassium hydroxide / ethanol / 0.5 h / Reflux

3.2: 20 °C / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hydride; sodium carbonate; hydrazine hydrate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 111627-26-0
1-(phenylsulfonyl)-4-piperidinecarboxylic acid ethyl ester

: 1636166-71-6
4-[2-{(2-bromobenzyl)thiol}-1,3,4-oxadiazol-5-yl]-1-(phenylsulfonyl)piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 20 °C / Reflux

2.1: potassium hydroxide / ethanol / 0.5 h / Reflux

2.2: 20 °C / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hydride; hydrazine hydrate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;