(R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine

Base Information

• Chemical Name: (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine
• CAS No.: 393513-95-6
• Molecular Formula: C10H14ClN3
• Molecular Weight: 211.694
• DSSTox Substance ID: DTXSID10470154
• Wikidata: Q72458727
• Mol file: 393513-95-6.mol

Synonyms:393513-95-6;(R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine;(3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine;SCHEMBL232057;DTXSID10470154;ZIHUFGHPYQTYIP-MRVPVSSYSA-N;AKOS005146075;A15549;(R)-1-(3-Chloro-pyridin-2-yl)-3-methyl-piperazine

Chemical Property of (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.541
• Boiling Point: 335.148 °C at 760 mmHg
• Flash Point: 156.492 °C
• PSA: 28.16000
• Density: 1.157g/cm³
• LogP: 1.92690
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 211.0876252
• Heavy Atom Count: 14
• Complexity: 188

Purity/Quality:

97% ^*data from raw suppliers

(R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN(CCN1)C2=C(C=CC=N2)Cl
• Isomeric SMILES: C[C@@H]1CN(CCN1)C2=C(C=CC=N2)Cl

Technology Process of (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine

There total 1 articles about (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,3-dichloro-pyridine (2402-77-9) + (2R)-methylpiperazine (75336-86-6) → (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine (393513-95-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 240 ℃; for 1h; microwave irradiation;

DOI:10.1021/jm060065y

Reference yield: 63.0%

4-(tert-butylbenzyl)isothiocyanate (19241-24-8) + (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine (393513-95-6) → C21H27ClN4S (393515-58-7)

Guidance literature:

In dichloromethane; at 25 ℃; for 5h;

Reference yield:

4-chloro-6-(4-fluorophenyl)-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyrimidine + (R)-1-(3-chloropyridin-2-yl)-3-methylpiperazine (393513-95-6) → 4-((R)-4-(3-chloropyridin-2-yl)-2-methylpiperazin-1-yl)-6-(4-fluorophenyl)-2-(2,5-dimethyl-1H-pyrrol-1-yl)pyrimidine

Guidance literature:

With potassium carbonate; In ISOPROPYLAMIDE; at 130 ℃; for 24h;

upstream raw materials:

2,3-dichloro-pyridine

(2R)-methylpiperazine

Downstream raw materials:

2-[4-(5-bromo-3-chloro-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

2-[4-(3-chloro-5-vinyl-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-trifluoromethyl-4-(3,4,5-trifluoro-phenyl)-1H-benzoimidazole

C₂₁H₂₇ClN₄S

N¹-(4-tert-butylphenyl)-N²-hydroxy-4-(3-chloropyridin-2-yl)-(R)-2-methylpiperazine-1-carboxamidine

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