1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea

Base Information

• Chemical Name: 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea
• CAS No.: 1419604-54-8
• Molecular Formula: C₂₅H₃₁ClF₃N₅O₂Si
• Molecular Weight: 554.087
• Mol file: 1419604-54-8.mol

Synonyms:1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea

Chemical Property of 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea

There total 13 articles about 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride (1419602-48-4) + phenyl 6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-ylcarbamate (1419604-52-6) → 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea (1419604-54-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 23 ℃; for 12h;

Reference yield:

3-nitro-2,6-lutidine (15513-52-7,767567-84-0) → 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea (1419604-54-8)

Guidance literature:

Multi-step reaction with 6 steps

1: selenium(IV) oxide / 1,4-dioxane / 16 h / 100 °C

2: sodium tetrahydroborate; methanol / 1 h / 0 °C

3: 1H-imidazole / dichloromethane / 1 h / 0 °C

4: hydrogen; palladium on activated charcoal / methanol / 16 h / 2068.65 Torr

5: pyridine / acetone / 4 h / 0 °C

6: triethylamine / dichloromethane / 12 h / 0 - 23 °C

With pyridine; 1H-imidazole; methanol; selenium(IV) oxide; sodium tetrahydroborate; palladium on activated charcoal; hydrogen; triethylamine; In 1,4-dioxane; methanol; dichloromethane; acetone;

Reference yield:

6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-amine (1419604-50-4) → 1-(6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-yl)-3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)urea (1419604-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / acetone / 4 h / 0 °C

2: triethylamine / dichloromethane / 12 h / 0 - 23 °C

With pyridine; triethylamine; In dichloromethane; acetone;

upstream raw materials:

(1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine monohydrochloride

phenyl 6-((tert-butyldimethylsilyloxy)methyl)-2-methylpyridin-3-ylcarbamate

3-nitro-2,6-lutidine

(6-methyl-5-nitropyridin-2-yl)methanol

Downstream raw materials:

1-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-3-(6-(hydroxymethyl)-2-methylpyridin-3-yl)urea