malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

Base Information

Chemical Name:malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester
CAS No.:899216-11-6
Molecular Formula:C₂₆H₃₇NO₁₁
Molecular Weight:539.58
Hs Code.:

malonic acid 3-(3-<i>tert</i>-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

Synonyms:malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

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Chemical Property of malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

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Technology Process of malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

There total 3 articles about malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 899216-10-5
[3-(3,5-bis-hydroxymethyl-phenoxy)-propyl]-carbamic acid tert-butyl ester

: 36239-09-5
ethyl chlorocarbonylacetate

: 899216-11-6
malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4.5h;
DOI:10.1002/chem.200600114

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 899216-11-6
malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂

2: 91 percent / K₂CO₃ / acetone / Heating

3: 56 percent / triethylamine / CH₂Cl₂ / 4.5 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetone;
DOI:10.1002/chem.200600114

Reference yield:

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 899216-11-6
malonic acid 3-(3-tert-butoxycarbonylamino-propoxy)-5-ethoxycarbonylacetoxymethyl-benzyl ester ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / K₂CO₃ / acetone / Heating

2: 56 percent / triethylamine / CH₂Cl₂ / 4.5 h / 20 °C

With potassium carbonate; triethylamine; In dichloromethane; acetone;
DOI:10.1002/chem.200600114