methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate

Base Information

• Chemical Name: methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate
• CAS No.: 231296-78-9
• Molecular Formula: C₁₈H₁₉NO₄S
• Molecular Weight: 345.419
• Mol file: 231296-78-9.mol

Synonyms:methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate

Chemical Property of methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate

There total 7 articles about methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2E)-3-(2-amino-5-ethylphenyl)acrylate (231296-77-8) + benzenesulfonyl chloride (98-09-9) → methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate (231296-78-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.ejmech.2012.01.053

Reference yield:

methyl (2E)-3-(2-amino-5-ethylphenyl)acrylate (231296-77-8) → methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate (231296-78-9)

Guidance literature:

Reference yield:

2-amino-1-bromo-5-ethylbenzene hydrochloride → methyl (2E)-3-{5-ethyl-2-[(phenylsulfonyl)amino]phenyl}acrylate (231296-78-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water

2: palladium diacetate; triethylamine; tris-(o-tolyl)phosphine / acetonitrile / 9 h / Inert atmosphere; Reflux

3: pyridine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With pyridine; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In ethanol; dichloromethane; water; acetonitrile; 2: Heck-Mizoroki cross-coupling;

DOI:10.1016/j.ejmech.2012.01.053

upstream raw materials:

methyl (2E)-3-(2-amino-5-ethylphenyl)acrylate

benzenesulfonyl chloride

N-(2-bromo-4-ethylphenyl)acetamide

2-bromine-4-ethylaniline