4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide
• CAS No.: 1606991-95-0
• Molecular Formula: C₁₇H₂₃N₇O₃S
• Molecular Weight: 405.481
• Mol file: 1606991-95-0.mol

Synonyms:4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide

Chemical Property of 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide

There total 5 articles about 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

valinol (16369-05-4,473-75-6) + 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzene-1-sulfonyl chloride (1606992-07-7) → 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide (1606991-95-0)

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1016/j.ejmech.2014.03.054

Reference yield:

C7H11N5S (960307-19-1) → 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide (1606991-95-0)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid

2: potassium permanganate; tetrabutylammomium bromide / acetic acid; benzene; water / 2 h / 20 °C

3: 216 h / 150 °C / Sealed tube

4: chlorosulfonic acid / 2 h / 20 °C / Inert atmosphere; Cooling with ice

5: acetonitrile / 20 °C

With chlorosulfonic acid; potassium permanganate; tetrabutylammomium bromide; toluene-4-sulfonic acid; In water; acetic acid; acetonitrile; benzene;

DOI:10.1016/j.ejmech.2014.03.054

Reference yield:

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine (682319-80-8) → 4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)-N-(1-hydroxy-3-methylbutan-2-yl)benzenesulfonamide (1606991-95-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium permanganate; tetrabutylammomium bromide / acetic acid; benzene; water / 2 h / 20 °C

2: 216 h / 150 °C / Sealed tube

3: chlorosulfonic acid / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4: acetonitrile / 20 °C

With chlorosulfonic acid; potassium permanganate; tetrabutylammomium bromide; In water; acetic acid; acetonitrile; benzene;

DOI:10.1016/j.ejmech.2014.03.054

upstream raw materials:

C₇H₁₁N₅S

valinol

4-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-ylamino)benzene-1-sulfonyl chloride

1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine