C₂₇H₃₃Cl₂FN₄O₃

Base Information

Chemical Name:C₂₇H₃₃Cl₂FN₄O₃
CAS No.:1332837-47-4
Molecular Formula:C₂₇H₃₃Cl₂FN₄O₃
Molecular Weight:551.488
Hs Code.:

C<sub>27</sub>H<sub>33</sub>Cl<sub>2</sub>FN<sub>4</sub>O<sub>3</sub>

Synonyms:C₂₇H₃₃Cl₂FN₄O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₇H₃₃Cl₂FN₄O₃

Chemical Property:

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Technology Process of C₂₇H₃₃Cl₂FN₄O₃

There total 7 articles about C₂₇H₃₃Cl₂FN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1332837-44-1
4-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-1H-pyrrolo[2,3-c]pyridin-5-ylamine

: 147699-19-2
tert-butyl 4-{2-[(methylsulfonyl)oxy]ethyl}piperidine-1-carboxylate

: 1332837-47-4
C₂₇H₃₃Cl₂FN₄O₃

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

Reference yield:

: 425380-38-7
4-bromo-7-chloro-3a,7a-dihydro-1H-pyrrolo[2,3-c]pyridine

: 1332837-47-4
C₂₇H₃₃Cl₂FN₄O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / tetrahydrofuran / 1 h

2.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

2.2: 4 h / 0 °C

3.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / 1 h / Reflux

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 20 °C

5.1: zinc; acetic acid / 16 h / 20 °C

6.1: hydrogenchloride; zinc / 1,4-dioxane; water / 1.5 h

7.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With hydrogenchloride; dmap; nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; bis(pinacol)diborane; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;

Reference yield:

: 1332837-54-3
C₁₂H₁₂BrClN₂O₂

: 1332837-47-4
C₂₇H₃₃Cl₂FN₄O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis(pinacol)diborane; potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

1.2: 4 h / 0 °C

2.1: toluene-4-sulfonic acid; nickel(II) nitrate hexahydrate / 1 h / Reflux

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / 2 h / 20 °C

4.1: zinc; acetic acid / 16 h / 20 °C

5.1: hydrogenchloride; zinc / 1,4-dioxane; water / 1.5 h

6.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

With hydrogenchloride; nickel(II) nitrate hexahydrate; di-isopropyl azodicarboxylate; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triphenylphosphine; bis(pinacol)diborane; zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;