(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

Base Information

Chemical Name:(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester
CAS No.:1421348-74-4
Molecular Formula:C₂₆H₃₀N₂O₂
Molecular Weight:402.536
Hs Code.:

Synonyms:(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

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Chemical Property of (+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

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Technology Process of (+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

There total 5 articles about (+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1873-55-8
3-methylquinoline N-oxide

: 1421348-73-3
(+/-)-4-[amino-(3,3-dimethyl-cyclobutyl)-methyl]-benzoic acid ethyl ester

: 1421348-74-4
(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 28h;

Reference yield:

: 612-58-8
3-methylquinoline

: 1421348-74-4
(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; acetic acid / water / 16 h / 80 °C

2: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 28 h / 20 °C

With dihydrogen peroxide; acetic acid; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; water;

Reference yield:

: 34970-18-8
3,3-dimethylcyclobutanecarboxylic acid

: 1421348-74-4
(+/-)-4-[(3,3-dimethyl-cyclobutyl)-(3-methyl-quinolin-2-ylamino)-methyl]-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane / 4 h / 20 °C

2.1: TurboGrignard / tetrahydrofuran / 2.25 h / -30 °C

2.2: 0.42 h / -30 - -20 °C

2.3: 4.08 h / -40 - 0 °C

3.1: sodium cyanoborohydride; ammonium acetate / methanol / 17 h / 60 °C

4.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 28 h / 20 °C

With TurboGrignard; oxalyl dichloride; ammonium acetate; sodium cyanoborohydride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane;