benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

Base Information

Chemical Name:benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate
CAS No.:928162-24-7
Molecular Formula:C₁₅H₁₈F₂N₂O₅S
Molecular Weight:376.381
Hs Code.:

Synonyms:benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

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Chemical Property of benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

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Technology Process of benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

There total 1 articles about benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 154350-29-5
cyclopropanesulphonamide

: 467438-39-7
(2S)-2-{[(benzyloxy)carbonyl]amino}-4,4-difluorobutanoic acid

: 928162-24-7
benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2006.11.003

Reference yield:

: 928162-24-7
benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

: 928162-29-2
C₃₆H₃₈F₂N₄O₈S

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol / 3 h

2: 0.173 g / HATU; ethyldiisopropylamine / dimethylformamide / 20 °C / pH 10

With hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.11.003

Reference yield:

: 928162-24-7
benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate

: C₃₁H₃₀F₂N₄O₆S*HCl

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol / 3 h

2: 0.173 g / HATU; ethyldiisopropylamine / dimethylformamide / 20 °C / pH 10

3: hydrochloric acid / dioxane / 20 °C

With hydrogenchloride; hydrogen; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.11.003