N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

Base Information

Chemical Name:N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide
CAS No.:1104623-01-9
Molecular Formula:C₂₂H₁₇F₂NO₂S₂
Molecular Weight:429.511
Hs Code.:

Synonyms:N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

Chemical Property:

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Technology Process of N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

There total 4 articles about N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1104623-99-5
(3,4-difluoro-benzyl)-(3-methyl-benzo[b]thiophen-2-yl)-amine

: 98-09-9
benzenesulfonyl chloride

: 1104623-01-9
N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

Guidance literature:: With pyridine; dmap; at 0 - 20 ℃;

Reference yield:

: 3133-78-6
3-methylbenzo[b]thiophene-2-carboxylic acid

: 1104623-01-9
N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 8 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

4.1: pyridine / dmap / 0 - 20 °C

With pyridine; diphenyl phosphoryl azide; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; dmap; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1104395-30-3
(3-methyl-benzo[b]thiophen-2-yl)-carbamic acid tert-butyl ester

: 1104623-01-9
N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: pyridine / dmap / 0 - 20 °C

With pyridine; sodium hydride; trifluoroacetic acid; dmap; In dichloromethane; N,N-dimethyl-formamide; mineral oil;