3133-78-6

Usage

Uses

Due to the limited information available on 3-methylbenzothiophene-2-carboxylic acid, its applications are not well-documented. However, based on its classification as a benzothiophene, it can be inferred that it may have potential uses in various industries, such as:
Used in Chemical Synthesis Industry:
3-Methylbenzothiophene-2-carboxylic acid could be used as a building block or intermediate in the synthesis of more complex organic compounds, particularly those with potential applications in pharmaceuticals, agrochemicals, or materials science.
Used in Research and Development:
In academic or industrial research settings, 3-methylbenzothiophene-2-carboxylic acid may be used as a subject of study to explore its chemical properties, reactivity, or potential applications in various fields.
Used in Material Science:
Given its heterocyclic structure, 3-methylbenzothiophene-2-carboxylic acid might be investigated for its potential use in the development of new materials with unique properties, such as electronic, optical, or mechanical characteristics.

InChI:InChI=1/C10H8O2S/c1-6-7-4-2-3-5-8(7)13-9(6)10(11)12/h2-5H,1H3,(H,11,12)/p-1

Upstream product

• 1455-18-1 3-methylbenzothiophene 
• 5381-23-7 2-bromo-3-methylbenzothiophene 
• 3216-47-5 3-chloromethylbenzothiophene 
• 573722-35-7 benzo[b]thiophen-3-ylmethyl-magnesium chloride 
• 15719-64-9 methylammonium carbonate 
• 60-29-7 diethyl ether 
• 541-41-3 chloroformic acid ethyl ester 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 68-11-1 mercaptoacetic acid 
• 124-38-9 carbon dioxide 
• 6314-28-9 benzo[b]thiophene-2-carboxylic acid 
• 75-24-1 trimethylaluminum 
• 3133-81-1 3-methylbenzo[b]thiophene-2-carboxylic acid methyl ester 
• 445-27-2 2'-Fluoroacetophenone 

Downstream Products

• 1455-18-1 3-methylbenzothiophene 
• 6406-91-3 3-methyl-1-benzothiophene-1,1-dioxide 
• 33357-85-6 3-methyl-2-nitrobenzo[b]thiophene 
• 1263757-42-1 2-(2,4,6-trifluorophenyl)-3-methylbenzo[b]thiophene 
• 1263757-12-5 3-methyl-2-(pentafluorophenyl)benzo[b]thiophene 
• 1263757-46-5 (2,4-difluoro-3-(3-methylbenzo[b]thiophen-2-yl)phenyl)-(phenyl)methanone 
• 1263757-48-7 methyl 3,5-difluoro-4-(3-methylbenzo[b]thiophen-2-yl)benzoate 
• 1104630-85-4 (3,4-difluoro-benzyl)-(3-methyl-benzo[b]thiophen-2-yl)-carbamic acid tert-butyl ester 
• 1104623-99-5 (3,4-difluoro-benzyl)-(3-methyl-benzo[b]thiophen-2-yl)-amine 
• 1104623-01-9 N-(3,4-difluoro-benzyl)-N-(3-methyl-benzo[b]thiophen-2-yl)-benzenesulfonamide 
• 5381-23-7 2-bromo-3-methylbenzothiophene 
• 50288-76-1 2-chloro-3-methylbenzothiophene 
• 41280-76-6 3-methylbenzo[b]thiophene-2-carbonyl chloride 

Relevant academic research and scientific papers

Iron-Catalyzed Ortho C-H Methylation of Aromatics Bearing a Simple Carbonyl Group with Methylaluminum and Tridentate Phosphine Ligand

Iron-catalyzed C-H functionalization of aromatics has attracted widespread attention from chemists in recent years, while the requirement of an elaborate directing group on the substrate has so far hampered the use of simple aromatic carbonyl compounds such as benzoic acid and ketones, much reducing its synthetic utility. We describe here a combination of a mildly reactive methylaluminum reagent and a new tridentate phosphine ligand for metal catalysis, 4-(bis(2-(diphenylphosphanyl)phenyl)phosphanyl)-N,N-dimethylaniline (Me2N-TP), that allows us to convert an ortho C-H bond to a C-CH3 bond in aromatics and heteroaromatics bearing simple carbonyl groups under mild oxidative conditions. The reaction is powerful enough to methylate all four ortho C-H bonds in benzophenone. The reaction tolerates a variety of functional groups, such as boronic ester, halide, sulfide, heterocycles, and enolizable ketones.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.

SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS

The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

Process for synthesizing substituted 2-benzo [b]thiophenecarboxylic acids and salts thereof

A process for the preparation of a substituted 2-benzo[b]thiophenecarboxylic acid compound or an alkali metal salt thereof, which comprises reacting a halobenzoyl derivative with mercaptoacetic acid in the presence of an alkali metal hydroxide and water. Substituted 2-benzo[b]thiophenecarboxylic acid compounds and alkali metal salts thereof are useful as intermediates for pharmaceuticals, agricultural chemicals, material preservatives, and the like.