methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Base Information

Chemical Name:methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate
CAS No.:1257397-82-2
Molecular Formula:C₃₀H₃₅F₆NO₂
Molecular Weight:555.604
Hs Code.:

Synonyms:methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

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Chemical Property of methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

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Technology Process of methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

There total 6 articles about methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257397-82-2
methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

1.2: 4 h / Reflux

2.1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

4.1: diethyl ether / 0.5 h / -40 - -30 °C

5.1: phosphorus tribromide / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C / Inert atmosphere

6.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; triethylamine; magnesium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: 155849-49-3
4-(trifluoromethyl)piperidine hydrochloride

: 1257397-81-1
methyl 2-(6-(1-bromo-2-cyclohexylethyl)-4'-(trifiuoromethyl)biphenyl-3-yl)acetate

: 1257397-82-2
methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: With triethylamine; In acetonitrile; at 80 ℃; for 1h;

Reference yield:

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1257397-82-2
methyl 2-(6-(2-cyclohexyl-1-(4-(trifluoromethyl)piperidin-1-yl)ethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

3: diethyl ether / 0.5 h / -40 - -30 °C

4: phosphorus tribromide / tetrahydrofuran; dichloromethane / 0.33 h / 20 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047