2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Base Information

Chemical Name:2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate
CAS No.:1257397-80-0
Molecular Formula:C₂₄H₂₇F₃O₃
Molecular Weight:420.472
Hs Code.:

Synonyms:2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

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Chemical Property of 2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

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Technology Process of 2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

There total 4 articles about 2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1257397-42-4
methyl 2-(6-formyl-4'-(trifluoromethyl)biphenyl-3-yl)acetate

: 35166-78-0
cyclohexylmethyl magnesium bromide

: 1257397-80-0
2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: methyl 2-(6-formyl-4'-(trifluoromethyl)biphenyl-3-yl)acetate; cyclohexylmethyl magnesium bromide; In diethyl ether; at -40 - -30 ℃;

With ammonium chloride; In diethyl ether; water;

Reference yield:

: 42058-59-3
3-hydroxy-benzeneacetic acid, methyl ester

: 1257397-80-0
2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 1.92 h / 40 °C

1.2: 4 h / Reflux

2.1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

4.1: diethyl ether / 0.5 h / -40 - -30 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; triethylamine; magnesium chloride; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047

Reference yield:

: 1257397-40-2
methyl 2-(4-formyl-3-hydroxyphenyl)acetate

: 1257397-80-0
2-(6-(2-cyclohexyl-1-hydroxyethyl)-4'-(trifluoromethyl)biphenyl-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / dichloromethane / 2 h / -12 - 0 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 100 °C / Microwave irradiation

3: diethyl ether / 0.5 h / -40 - -30 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.10.047